Sortilin and retromer mediate retrograde transport of Glut4 in 3T3-L1 adipocytes
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چکیده
منابع مشابه
Sortilin and retromer mediate retrograde transport of Glut4 in 3T3-L1 adipocytes
Sortilin is a multiligand sorting receptor responsible for the anterograde transport of lysosomal enzymes and substrates. Here we demonstrate that sortilin is also involved in retrograde protein traffic. In cultured 3T3-L1 adipocytes, sortilin together with retromer rescues Glut4 from degradation in lysosomes and retrieves it to the TGN, where insulin--responsive vesicles are formed. Mechanisti...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2017
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e16-11-0777